Selected Publications:

 

 Honda K*, Littman DR*. The microbiota in adaptive immune homeostasis and disease. Nature 535: 75-84 (2016)

 

・  {C}Saito T, Nishikawa H, Wada H, Nagano Y, Sugiyama D, Atarashi K, Maeda Y, Hamaguchi M, Ohkura N, Sato E, Nagase H, Nishimura J, Yamamoto H, Takiguchi S, Tanoue T, Suda W, Morita H, Hattori M, Honda K, Mori M, Doki Y, Sakaguchi S.  Two FOXP3(+)CD4(+) T cell subpopulations distinctly control the prognosis of colorectal cancers. Nat Med. 22(6):679-84 (2016)

 

・  {C}Ramanan D, Bowcutt R, Lee SC, Tang MS, Kurtz ZD, Ding Y, Honda K, Gause WC, Blaser MJ, Bonneau RA, Lim YA, Loke P, Cadwell K. Helminth infection promotes colonization resistance via type 2 immunity. Science. 352(6285):608-12 (2016).

 

・ Mathewson ND, Jenq R, Mathew AV, Koenigsknecht M, Hanash A, Toubai T, Oravecz-Wilson K, Wu SR, Sun Y, Rossi C, Fujiwara H, Byun J, Shono Y, Lindemans C, Calafiore M, Schmidt TC, Honda K, Young VB, Pennathur S, van den Brink M, Reddy P. Gut microbiome-derived metabolites modulate intestinal epithelial cell damage and mitigate graft-versus-host disease. Nat Immunol. 17(5):505-13 (2016)

{C}

 

 Atarashi K, Tanoue T, Ando M, Kamada N, Nagano Y, Narushima S, Suda W, Imaoka A, Setoyama H, Nagamori T, Ishikawa E, Shima T, Hara T, Kado S, Jinnohara T, Ohno H, Kondo T, Toyooka K, Watanabe E, Yokoyama S, Tokoro S, Mori H, Noguchi Y, Morita H, Ivanov II, Sugiyama T, Nuñez G, Camp JG, Hattori M, Umesaki* Y, Honda K*. Th17 cell induction by adhesion of microbes to intestinal epithelial cells. Cell. 163(2):367-80 (2015)  *corresponding authors

 

・  Ohnmacht C, Park JH, Cording S, Wing JB, Atarashi K, Obata Y, Gaboriau-Routhiau V, Marques R, Dulauroy S, Fedoseeva M, Busslinger M, Cerf-Bensussan N, Boneca IG, Voehringer D, Hase K, Honda K, Sakaguchi S, Eberl G. The microbiota regulates type 2 immunity through RORγt+ T cells. Science. DOI: 10.1126/science.aac4263 (2015)

 

・  Horai R, Zárate-Bladés CR, Dillenburg-Pilla P, Chen J, Kielczewski JL, Silver PB, Jittayasothorn Y, Chan CC, Yamane H, Honda K, Caspi RR. Microbiota-Dependent Activation of an Autoreactive T Cell Receptor Provokes Autoimmunity in an Immunologically Privileged Site. Immunity. 43:343-53. (2015)

 

・    Atarashi K, Tanoue T, Oshima K, Suda W, Nagano Y, Nishikawa H, Fukuda S, Saito T, Narushima S, Hase K, Kim S, Fritz JV, Wilmes P, Ueha S, Matsushima K, Ohno H, Olle B, Sakaguchi S, Taniguchi T, Morita H, Hattori M*, Honda K*. Treg induction by a rationally selected mixture of Clostridia strains from the human microbiota. Nature 500:232-236. (2013) 

 

・    Yoshimoto S, Loo TM, Atarashi K, Kanda H, Sato S, Oyadomari S, Iwakura Y, Oshima K, Morita H, Hattori M, Honda K, Ishikawa Y, Hara E, Ohtani N. Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome. Nature 499:97-101. (2013)

 

・    Mucida D, Husain MM, Muroi S, van Wijk F, Shinnakasu R, Naoe Y, Reis BS, Huang Y, Lambolez F, Docherty M, Attinger A, Shui JW, Kim G, Lena CJ, Sakaguchi S, Miyamoto C, Wang P, Atarashi K, Park Y, Nakayama T, Honda K, Ellmeier W, Kronenberg M, Taniuchi I, Cheroutre H. Transcriptional reprogramming of mature CD4⁺ helper T cells generates distinct MHC class II-restricted cytotoxic T lymphocytes. Nat Immunol. 14:281-9. (2013)

 

・    Ivanov II*, Honda K*. Intestinal commensal microbes as immune modulators. Cell Host Microbe. 12:496-508. (2012) 

 

・    Honda K*, Littman DR*. The microbiome in infectious disease and inflammation. Ann Rev Immunol. 30:759-95. (2012) 

 

・    Induction of colonic regulatory T cells by indigenous Clostridium species. Atarashi K, Tanoue T, Shima T, Imaoka A, Kuwahara T, Momose Y, Cheng G, Yamasaki S, Saito T, Ohba Y, Taniguchi T, Takeda K, Hori S, Ivanov II, Umesaki Y, Itoh K and Honda K*. Science 331:337-341 (2011)  

 

・    Induction of intestinal Th17 cells by segmented filamentous bacteria. Ivanov II, Atarashi K, Manel N, Brodie EL, Shima T, Karaoz U, Wei D, Goldfarb KC, Santee CA, Lynch SV, Tanoue T, Imaoka A, Itoh K, Takeda K, Umesaki Y, Honda K*, Littman DR*. Cell 139:485-98. (2009) 

 

・    HMGB proteins function as universal sentinels for nucleic-acid-mediated innate immune responses.  Yanai H, Ban T, Wang Z, Choi MK, Kawamura T, Negishi H, Nakasato M, Lu Y, Hangai S, Koshiba R, Savitsky D, Ronfani L, Akira S, Bianchi ME, Honda K, Tamura T, Kodama T, Taniguchi T. Nature. 462:99-103. (2009)

 

・    Negishi H, Osawa T, Ogami K, Ouyang X, Sakaguchi S, Koshiba R, Yanai H, Seko Y, Shitara H, Bishop K, Yonekawa H, Tamura T, Kaisho T, Taya C, Taniguchi T, Honda K. A critical link between Toll-like receptor 3 and type II interferon signaling pathways in antiviral innate immunity. Proc Natl Acad Sci U S A. 105:20446-51. (2008)

 

・    Atarashi K, Nishimura J, Shima T, Umesaki Y, Yamamoto M, Onoue M, Yagita H, Ishii N, Evans R, Honda K*, Takeda K*. ATP drives lamina propria T(H)17 cell differentiation. Nature 455:808-12. (2008) 

 

・    Kano SI., Sato K., Morishita Y., Vollstedt S., Kim S., Bishop K., Honda K., Kubo M., Taniguchi T.  The contribution of transcription factor IRF1 to the interferon-gamma-interleukin 12 signaling axis and T(H)1 versus T(H)-17 differentiation of CD4(+) T cells. Nature Immunology 9: 34–41. (2008).

 

・    Takaoka A, Wang Z, Choi MK, Yanai H, Negishi H, Ban T, Lu Y, Miyagishi M, Kodama T, Honda K, Ohba Y, Taniguchi T. DAI (DLM-1/ZBP1) is a cytosolic DNA sensor and an activator of innate immune response. Nature 448:501-5. (2007)

 

・    Yanai, H., H.M. Chen, T. Inuzuka, S. Kondo, T.W. Mak, A. Takaoka, K. Honda, and T. Taniguchi.  Role of IRF5 transcription factor in antiviral immunity and tumor suppression. Proc Natl Acad Sci U S A. 104:3402-3407. (2007)

 

・    Negishi, H., Y. Fujita, H. Yanai, S. Sakaguchi, X. Ouyang, M. Shinohara, H. Takayanagi, Y. Ohba, T. Taniguchi, and K. Honda. Evidence for licensing of IFN-γ-induced IRF1 transcription factor by MyD88 in TLR-dependent gene induction program.  Proc Natl Acad Sci U S A. 103:15136-15141. (2006).

 

・    Honda, K., A. Takaoka, and T. Taniguchi. Type I interferon gene induction by the interferon regulatory factor family of transcription factors.  Immunity 25:349-360. (2006).

 

・    Honda, K., and T. Taniguchi.  IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors. Nature Reviews Immunology 6:644-658. (2006).

 

・    Negishi, H., Y. Ohba, H. Yanai, A. Takaoka, K. Honma, K. Yui, T. Matsuyama, T. Taniguchi, and K. Honda.  Negative regulation of Toll-like-receptor signaling by IRF-4.  Proc Natl Acad Sci U S A. 102:15989-15994. (2005).

 

・    Takaoka, A., H. Yanai, S. Kondo, G. Duncan, H. Negishi, T. Mizutani, S. Kano, K. Honda, Y. Ohba, T. W. Mak, and T. Taniguchi.  Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors.  Nature 434:243-249. (2005).

 

・    Honda, K., H. Yanai, H. Negishi, M. Asagiri, M. Sato, T. Mizutani, N. Shimada, Y. Ohba, A. Takaoka, N. Yoshida, and T. Taniguchi.  IRF-7 is the master regulator of type-I interferon-dependent immune responses.  Nature 434:772-777. (2005).

 

・    Honda, K., Y. Ohba, H. Yanai, H. Negishi, T. Mizutani, A. Takaoka, C. Taya, and T. Taniguchi.  Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction. Nature 434:1035-1040. (2005).

 

・    Honda, K., H. Yanai, T. Mizutani, H. Negishi, N. Shimada, N. Suzuki, Y. Ohba, A. Takaoka, W. C. Yeh, and T. Taniguchi. Role of a transductional- transcriptional processor complex involving MyD88 and IRF-7 in Toll-like receptor signaling. Proc Natl Acad Sci U S A. 101:15416-15421. (2004).

 

・    Honda, K., T. Mizutani, and T. Taniguchi.  Negative regulation of IFN-α/β signaling by IFN regulatory factor 2 for homeostatic development of dendritic cells. Proc Natl Acad Sci U S A. 101:2416-2421. (2004). 

 

・    Takaoka, A., S. Hayakawa, H. Yanai, D. Stoiber, H. Negishi, H. Kikuchi, S. Sasaki, K. Imai, T. Shibue, K. Honda, and T. Taniguchi.  Integration of interferon-α/β signalling to p53 responses in tumour suppression and antiviral defence. Nature 424:516-523. (2003).

 

・    Honda, K., S. Sakaguchi, C. Nakajima, A. Watanabe, H. Yanai, M. Matsumoto, T. Ohteki, T. Kaisho, A. Takaoka, S. Akira, T. Seya, and T. Taniguchi.  Selective contribution of IFN-α/β signaling to the maturation of dendritic cells induced by double-stranded RNA or viral infection. Proc Natl Acad Sci U S A. 100:10872-10877. (2003).

 

・    Honda, K*., Nakano, H., Yoshida, H., Nishikawa, S., Rennert, P., Ikuta, K., Tamechika, M., Yamaguchi, K., Fukumoto, T., Chiba, T., and Nishikawa, S.I.  Molecular basis for hematopoietic / mesenchymal interaction during initiation of Peyer’s patch organogenesis. J. Exp. Med. 193:621-630 (2001).

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